New Diabetes Curetom Hawks What Are Diabetic Pumps. Nandrolone Wikipedia. Nandrolone. Clinical data. Pronunciation3Trade names. Where Is The Serial Number On Sennheiser Headphones. Deca Durabolin as nandrolone decanoate, Durabolin as nandrolone phenylpropionate, others. Synonyms. Nortestosterone 1. Nortestosterone Estr 4 en 1. Norandrost 4 en 1. Hydroxyestr 4 en 3 one 1. Nortestosterone Norandrostenolone Nortestrionate Nortestonate Oestrenolone Estrenolone SG 4. Pregnancycategory. AU DUS X ContraindicatedRoutes ofadministration. Intramuscular injection as an esterDrug class. Androgen Anabolic steroid Progestogen. ATC code. Legal status. Legal status. Pharmacokinetic data. Bioavailability. Oral 2citation neededIntramuscular 1. Metabolism. Hepatic. Identifiers8. R,9. S,1. 0R,1. 3S,1. 4S,1. S 1. 7 hydroxy 1. H cyclopentaaphenanthren 3 one. CAS Number. Pub. Chem. 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YKey NPAGDVCDWIYMMC IZPLOLCNSA N Y NY what is this  verifyNandrolone is an injectedanabolicandrogenic steroid AAS which is used medically in the form of esters such as nandrolone decanoate brand name Deca Durabolin and nandrolone phenylpropionate brand name Durabolin. They are not active by mouth, and must be administered via intramuscular injection. When administered in this way, they form a depot from which they are slowly released, and hence have a long duration of action. Nandrolone esters are prodrugs, and are rapidly hydrolyzed into nandrolone once in the circulation. Medical useseditNandrolone esters are used clinically, although increasingly rarely, for people in catabolic states with major burns, cancer, and AIDS, and an ophthalmological formulation was available to support cornea healing. Non medical useseditNandrolone esters are used for physique and performance enhancing purposes by competitiveathletes, bodybuilders, and powerlifters. PharmacologyeditPharmacodynamicseditThe positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production,medical citation needed and bone density. Clinical studies have shown it to be effective in treating anemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin based contraceptive. Unlike testosterone and certain other AAS, nandrolone is not potentiated in androgenic tissues like the scalp, skin, and prostate, and hence, deleterious effects in these tissues are lessened to a degree. This is because nandrolone is metabolized by 5 reductase to the much weaker androgen 5 dihydronandrolone DHN, which has both reduced affinity for the androgen receptor AR relative to nandrolone in vitro and weaker androgenic activity in vivo. The lack of alkylation on the 1. Estrogen effects resulting from reaction with aromatase are also reduced due to lessened enzyme interaction,9 but effects such as gynaecomastia and reduced libido may still occur at sufficiently high doses. Other side effects of high doses of nandrolone can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drugs effect of lowering levels of luteinizing hormone through negative feedback. Erectile dysfunction is attributed to the weaker action of DHN in the penis since dihydrotestosterone DHT is a known sexual modulator. In addition to its androgenic activity, unlike many other AAS, nandrolone is also a potent progestogen. It binds to the progesterone receptor with approximately 2. The progestogenic activity of nandrolone may serve to augment its antigonadotropic effects,1. Anabolic and androgenic activityeditNandrolone has a very high ratio of anabolic to androgenic activity. In fact, nandrolone like AAS like nandrolone itself and trenbolone are said to have among the highest ratio of anabolic to androgenic effect of all AAS. This is attributed to the fact that, whereas testosterone is potentiated via conversion into dihydrotestosterone DHT in androgenic tissues, the opposite is true with nandrolone and similar AAS i. As such, nandrolone like AAS, namely nandrolone esters, are the most frequently used AAS in clinical settings in which anabolic effects are desired for instance, in the treatment of AIDS associated cachexia, severe burns, and chronic obstructive pulmonary disease. However, AAS with a very high ratio of anabolic to androgenic action like nandrolone still have significant androgenic effects and can produce symptoms of virilization like hirsutism and voice deepening in women and children with extended use. PharmacokineticseditMetabolismeditNandrolone is metabolized by the enzyme. Metabolites of nandrolone include 5 dihydronandrolone, 1. Chemistryedit. Nandrolone, with the differences from testosterone highlighted in red. The methyl group in testosterone at the C1. C1. 7 position is where esters are attached to nandrolone. Nandrolone, also known as 1. NT or as estrenolone, as well as estra 4 en 1. It is specifically the C1. Nandrolone esters have an ester such as decanoate or phenylpropionate attached at the C1. DerivativeseditA variety of esters of nandrolone have been marketed and used medically. The most commonly used esters are nandrolone decanoate and to a lesser extent nandrolone phenylpropionate. Examples of other nandrolone esters include nandrolone cyclohexylpropionate, nandrolone cypionate, nandrolone hexyloxyphenylpropionate, nandrolone laurate, nandrolone sulfate, and nandrolone undecanoate. Anabolic steroidseditNandrolone is the parent compound of a large group of AAS. Notable examples include the non 1. R 1. 88. 1, as well as the 1. THG. The following is list of derivatives of nandrolone that have been developed as AAS 6ProgestinseditNandrolone, together with ethisterone 1. This family is subdivided into two groups the estranes and the gonanes. The estranes include norethisterone norethindrone, norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and noretynodrel, while the gonanes include norgestrel, levonorgestrel, desogestrel, etonogestrel, gestodene, norgestimate, dienogest actually a 1. SynthesiseditThe elaboration of a method for the reduction of aromatic rings to the corresponding dihydrobenzenes under controlled conditions by A. J. Birch opened a convenient route to compounds related to the putative 1. This reaction, now known as the Birch reduction,2. Initial reaction constituents of 1,4 dimetalation of the most electron deficient positions of the aromatic ringin the case of an estrogen, the 1 and 4 positions. Rxn of the intermediate with the proton source leads to a dihydrobenzene a special virtue of this sequence in steroids is the fact that the double bind at 2 is in effect becomes an enol ether moiety. Treatment of this product 2 with weak acid, oxalic acid for e. Hydrolysis under more strenuous conditions mineral acids results in migrationconjugation of the olefin to yield nandrolone 4. Treatment of 4 with decanoic anhydride and pyridine affords nandrolone decanoate. Acylation of 4 with phenylpropionyl chloride yields nandrolone phenpropionate.